Despite the advantages, support engineering faces several challenges:
Sintering: High temperatures can cause the active sites to agglomerate, reducing the catalyst's effectiveness. Leaching: In liquid-phase reactions, the active sites or support material itself can dissolve, leading to catalyst deactivation. Poisoning: Contaminants can adsorb onto the active sites or the support, blocking the reaction. Complex Interactions: The interactions between the support and the active sites can be complex and not always beneficial.
