What are the Challenges Associated with Using Host Cells?
Despite their advantages, the use of host cells in catalysis also presents some challenges:
Complexity of Cellular Systems: The intracellular environment is complex and can sometimes hinder the activity or stability of the introduced catalytic enzymes. Regulatory Issues: The use of genetically modified organisms (GMOs) often involves stringent regulatory requirements, which can complicate their application in industrial processes. Scale-Up Difficulties: While laboratory-scale experiments may be successful, scaling up the production process in host cells can be challenging and requires optimization of growth conditions, nutrient supply, and other parameters.
