What are Some Common Types of C-C Coupling Reactions?
Several types of C-C coupling reactions are widely utilized in organic synthesis:
Suzuki-Miyaura Coupling: This reaction involves the coupling of an aryl or vinyl boronic acid with an aryl or vinyl halide, typically catalyzed by palladium. Heck Reaction: This reaction couples alkenes with aryl halides in the presence of a palladium catalyst. Stille Coupling: This reaction involves the coupling of organotin compounds with aryl or vinyl halides, catalyzed by palladium. Negishi Coupling: This method uses organozinc compounds and aryl or vinyl halides in the presence of a palladium or nickel catalyst. Sonogashira Coupling: This reaction couples terminal alkynes with aryl or vinyl halides, typically catalyzed by palladium and copper.
