What are the Challenges in C-C Coupling Reactions?
Despite their utility, C-C coupling reactions face several challenges:
Reactivity: Some substrates may be less reactive, necessitating the use of more robust or specialized catalysts. Selectivity: Achieving high selectivity can be difficult, particularly in complex molecules with multiple reactive sites. Cost: Many effective catalysts, such as those based on palladium, are expensive and can increase the overall cost of the reaction. Environmental Concerns: Some catalysts and reagents used in C-C coupling reactions can be toxic or environmentally harmful.
