What are Some Challenges and Limitations of Using 13C in Catalysis?
Despite its advantages, the use of 13C in catalysis is not without challenges. The primary limitation is the cost, as 13C-enriched compounds are more expensive than their 12C counterparts. Additionally, the sensitivity of 13C-NMR is lower compared to 1H-NMR, requiring higher concentrations of the 13C-labeled compounds or longer data acquisition times. Nevertheless, the benefits of using 13C in mechanistic studies often outweigh these challenges.
