How Does Ornithine Aminotransferase Function as a Catalyst?
OAT functions as a biocatalyst by accelerating the transamination reaction between ornithine and α-ketoglutarate. The enzyme lowers the activation energy required for the reaction, thereby increasing the reaction rate. The catalytic mechanism involves the formation of a Schiff base intermediate between the amino group of ornithine and the cofactor pyridoxal phosphate (PLP), which is essential for the enzyme's activity.
