Malfunctioning peroxisomes can lead to a variety of metabolic disorders, collectively known as peroxisomal biogenesis disorders (PBDs). These disorders often result from mutations in genes encoding peroxisomal proteins, disrupting the organelle's catalytic functions. Conditions such as Zellweger syndrome are characterized by impaired fatty acid metabolism and an accumulation of toxic intermediates, highlighting the critical role of peroxisomal catalysis in human health.
