What Are Common Strategies for Ligand Modification?
Several strategies are employed to modify ligands, including: - Substitution: Replacing one ligand with another to change the electronic or steric properties. - Functionalization: Adding functional groups to existing ligands to alter their reactivity or binding properties. - Ligand Design: Creating entirely new ligands with specific properties tailored to the desired catalytic reaction. - Chiral Ligands: Introducing chiral centers to ligands to achieve enantioselective catalysis, which is important for producing chiral molecules in pharmaceuticals.
