Hexokinase regulation is multifaceted and involves several mechanisms, including feedback inhibition by its product, glucose-6-phosphate. Additionally, different isoforms of hexokinase exist, each with distinct regulatory properties and tissue-specific expression. For example, hexokinase IV, also known as glucokinase, is found in the liver and pancreas and has a lower affinity for glucose compared to other isoforms, making it more responsive to changes in blood glucose levels.
