In the context of catalysis, the deficiency of alpha-galactosidase A is significant because enzymes are biological catalysts. Catalysts speed up chemical reactions without being consumed in the process. Alpha-galactosidase A specifically catalyzes the hydrolysis of GL-3 into simpler molecules. In patients with Fabry Disease, the mutation in the gene coding for this enzyme results in insufficient catalytic activity, leading to the harmful buildup of GL-3.
