pemetrexed

How Does Pemetrexed Work?

Pemetrexed inhibits three key enzymes: thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). These enzymes are essential for the synthesis of thymidine and purine nucleotides, which are vital for DNA and RNA synthesis. By inhibiting these enzymes, pemetrexed effectively hampers the proliferation of rapidly dividing cancer cells.

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