Catalysis in histone acetylation involves the enzyme-mediated transfer of an acetyl group from acetyl-CoA to the ε-amino group of lysine residues on histones. This enzymatic activity can modulate the interaction between histones and DNA, effectively acting as a regulatory mechanism for gene transcription. In this context, HATs serve as the catalysts that facilitate the acetylation reaction, while histone deacetylases (HDACs) act as the reverse catalysts, removing acetyl groups.
