Catalysts can improve the Mannich Reaction in several ways:
Rate Enhancement: Catalysts lower the activation energy, increasing the reaction rate significantly. Selectivity: Enantioselective catalysts can help produce a single enantiomer, which is often crucial in drug synthesis. Milder Conditions: The use of catalysts often allows reactions to proceed under milder conditions, reducing the risk of side reactions. Sustainability: Catalysts can make processes more sustainable by reducing the need for excess reagents and minimizing waste.
