How do Statins Selectively Inhibit HMG-CoA Reductase?
Statins are designed to be highly selective for HMG-CoA Reductase, minimizing side effects by not inhibiting other enzymes in the body. This selectivity is achieved through the precise fit of the statin molecule within the enzyme’s active site. The molecular structure of statins is optimized to interact with specific amino acid residues in the active site, ensuring that the inhibition is both strong and specific. This exemplifies the principles of molecular recognition in catalysis.
