[Enzymes](https://) are natural catalysts that can be engineered to enhance the efficacy of anticancer drugs. Enzyme-catalyzed reactions are highly specific, which makes them ideal for targeting cancer cells while sparing normal cells. Enzymes such as [cytochrome P450](https://) can be engineered to metabolize prodrugs specifically within tumor tissues, thereby increasing the local concentration of the active drug and minimizing systemic toxicity.
