How Can MMR Enzymes be Targeted for Therapeutic Purposes?
Understanding the catalytic mechanisms of MMR enzymes opens avenues for developing targeted therapies. For example, exploiting the vulnerabilities of MMR-deficient cells has led to the development of immunotherapies that target tumors with high MSI. Additionally, small molecules that modulate the activity of MMR enzymes could potentially be used to enhance DNA repair in conditions where MMR activity is compromised.