Histone modifications are studied using a range of techniques. Chromatin immunoprecipitation (ChIP) followed by sequencing (ChIP-seq) is commonly used to map histone modifications across the genome. Mass spectrometry can identify and quantify specific histone modifications. Additionally, enzyme assays are employed to study the activity of histone-modifying enzymes. These techniques provide insights into the distribution and functional impact of histone modifications in various biological contexts.
