Why are Histone Modifications Important in Disease?
Aberrations in histone modification patterns are linked to various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. For example, overexpression or mutation of certain HMTs and HDACs has been observed in specific cancers. Targeting these enzymes with small molecule inhibitors can potentially reverse abnormal histone modifications and restore normal gene expression patterns. This has led to the development of HDAC inhibitors and HMT inhibitors as therapeutic agents.
