Optimization of Fenton-like reactions involves several strategies. One approach is to modify the nature of the catalyst by using different transition metals or employing nanoscale catalysts to enhance surface area and reactivity. Another strategy is to use chelating agents that can stabilize the metal ions and improve their reactivity. Additionally, advanced techniques like photo-Fenton and electro-Fenton processes can be employed to enhance the generation of hydroxyl radicals through the application of light or electrical energy.