Can MMPs be Targeted for Therapeutic Interventions?
Given their role in various diseases, MMPs are considered potential therapeutic targets. Inhibitors of MMPs, including small molecules and monoclonal antibodies, are being developed to modulate their activity. However, the broad specificity and essential physiological functions of MMPs pose challenges in designing selective and safe inhibitors. Balancing the inhibition of pathological MMP activity while preserving their normal physiological roles remains a critical aspect of therapeutic development.
