Using immobilized enzymes offers several advantages over free enzymes. First, they provide enhanced stability against environmental changes such as pH and temperature. Second, they facilitate easy separation from reaction mixtures, allowing for enzyme reuse and reducing costs. Third, immobilized enzymes can achieve higher concentrations of enzyme per unit volume, which can lead to increased reaction rates. Lastly, they minimize contamination of the product by the enzyme, which is crucial in industries like pharmaceuticals and food production.