CO insertion is vital for several catalytic cycles, especially those involved in carbon-carbon bond formation. The process is a key step in the hydroformylation of alkenes, where an olefin, CO, and Hâ react to form an aldehyde. It's also essential in the Reppe chemistry for producing acrylic acid derivatives and in the Monsanto process for acetic acid production. These reactions are cornerstones of industrial chemistry, showcasing the importance of CO insertion in creating valuable chemicals from simple precursors.