What Are the Challenges in CO Insertion Catalysis?
Despite its utility, CO insertion catalysis faces several challenges:
- Selectivity: Achieving high regioselectivity and chemoselectivity can be difficult, particularly in complex molecules with multiple reactive sites. - Catalyst Stability: Many transition metal catalysts are prone to deactivation through aggregation or formation of inactive species. - Toxicity and Handling of CO: Carbon monoxide is a toxic gas, requiring stringent safety measures during industrial handling and usage.
