Aldehydes are reactive and potentially toxic compounds. The [detoxification](https://en.wikipedia.org/wiki/Detoxification) of aldehydes by ALDH is vital for cellular health. For example, acetaldehyde, a byproduct of ethanol metabolism, is highly toxic and is effectively converted to acetic acid by ALDH. Impaired ALDH function is linked to various health issues, including alcohol intolerance, cancer, and neurodegenerative diseases.