The motivation to explore alternative reaction media stems from several factors:
Sustainability: Many alternative media are considered more environmentally friendly compared to traditional organic solvents. Safety: Reduced flammability and toxicity of some alternative media improve safety in industrial and laboratory settings. Efficiency: Enhanced solubility, mass transfer, and reaction rates can be achieved in certain media. Novel Reactivity: Unusual reactivity and selectivity patterns can be observed, opening new pathways for synthesis.
