Which Amino Acid Residues are Commonly Involved in Catalysis?
Some amino acid residues are more frequently involved in catalysis due to their specific chemical properties: - Histidine: Often acts as a proton donor or acceptor due to its imidazole side chain. - Serine: Functions as a nucleophile in serine proteases. - Aspartate and Glutamate: Act as acid/base catalysts or help in substrate binding. - Cysteine: Can form covalent bonds with substrates, often seen in cysteine proteases. - Lysine: Involved in forming Schiff bases with substrate molecules.
