What Therapeutic Strategies Target Misfolded Proteins?
Therapeutic strategies to mitigate the effects of misfolded proteins include enhancing the activity of molecular chaperones, using small molecules to stabilize proper protein folding, and promoting the degradation of misfolded proteins. For instance, pharmacological chaperones can bind to and stabilize specific proteins, aiding in their correct folding. Proteostasis regulators can enhance the cell's natural ability to manage misfolded proteins, thereby reducing toxicity.
