Future research on PLpro will likely focus on improving the selectivity and potency of inhibitors while minimizing off-target effects. Developing broad-spectrum inhibitors that can target multiple coronaviruses is also a critical goal. Additionally, understanding the enzyme's role in host-pathogen interactions could reveal new therapeutic strategies. Combining PLpro inhibitors with other antiviral agents may offer synergistic effects, enhancing the overall efficacy of treatment regimens.
