The catalytic activity of rRNAs is primarily attributed to the large subunit, particularly the 23S rRNA in prokaryotes and the 28S rRNA in eukaryotes. This region of the rRNA is known as the peptidyl transferase center (PTC). The PTC catalyzes the formation of peptide bonds between amino acids during protein synthesis. This ribozyme activity of rRNAs underscores their importance in the catalytic function of ribosomes.
