Paraoxonase (PON) refers to a family of enzymes that play a significant role in the hydrolysis of organophosphates, aromatic carboxylic acid esters, and lactones. These enzymes are crucial in the detoxification of harmful substances such as pesticides and nerve agents. The three main types of paraoxonases are PON1, PON2, and PON3, each exhibiting distinct substrate specificities and tissue distribution.