Operando mass spectrometry (MS) is an advanced analytical technique used to study catalytic processes in real-time under actual operating conditions. The term "operando" originates from Latin, meaning "working" or "operating," and in the context of catalysis, it refers to simultaneous measurement of catalytic activity and the elucidation of the reaction mechanism during the catalytic process. By providing detailed insights into the dynamic behavior of catalysts, operando MS has become an indispensable tool in the field of catalysis.