1. Complex Design: Designing and scaling up a PFR can be more complex compared to other types of reactors, especially for reactions with complex kinetics. 2. Maintenance: PFRs can be more challenging to clean and maintain, particularly in processes where fouling or catalyst deactivation is an issue. 3. Pressure Drop: The long, narrow design of a PFR can lead to significant pressure drops, which may require additional pumping power.
