What are the Key Enzymes Involved in Immune Evasion?
Several enzymes have been identified as key players in immune evasion. Some of the most notable include:
Indoleamine 2,3-dioxygenase (IDO): This enzyme degrades tryptophan, an essential amino acid for T-cell proliferation, thereby suppressing the immune response. Arginase: By depleting arginine, another amino acid necessary for T-cell function, arginase can inhibit T-cell activity and promote immune evasion. Matrix Metalloproteinases (MMPs): These enzymes can degrade extracellular matrix components and release growth factors that facilitate tumor growth and metastasis, thereby aiding in immune evasion.
