In biological systems, enzymes known as methyltransferases play a critical role in remethylation. These enzymes are highly specific and efficient, making them vital for the regulation of various biological processes. In contrast, industrial remethylation often utilizes metal-based catalysts such as palladium, ruthenium, and nickel complexes. These catalysts are chosen for their ability to facilitate the transfer of methyl groups under mild conditions, thereby improving reaction efficiency and selectivity.