What are the Consequences of Dysregulated Respiratory Burst?
While the respiratory burst is vital for pathogen clearance, its dysregulation can lead to tissue damage and various diseases. Excessive ROS production can cause oxidative stress, contributing to inflammatory diseases, atherosclerosis, and cancer. Conversely, insufficient ROS production, as seen in chronic granulomatous disease, results in recurrent infections due to the inability to effectively kill pathogens.
