Despite its importance, chiral chromatography has several challenges:
Cost: Chiral stationary phases can be expensive, making large-scale separations costly. Complexity: The separation process can be complex and may require multiple steps to achieve high purity. Scalability: Scaling up chiral separations from analytical to preparative scale can be challenging. Selectivity: Achieving high selectivity for certain enantiomers can be difficult and may require extensive optimization.
