Despite its advantages, catalytic screening faces several challenges:
Complexity of Reactions: Many chemical reactions are complex, with multiple pathways and intermediates. This complexity can make it difficult to identify the most efficient catalyst. Reproducibility: Ensuring that catalytic screening results are reproducible can be challenging, particularly when dealing with heterogeneous catalysts. Scalability: Catalysts that perform well on a small scale may not always be scalable to industrial levels. Environmental and Economic Considerations: The need for sustainable and cost-effective catalysts adds additional layers of complexity to the screening process.