What are the Challenges in Asymmetric Epoxidation?
Despite its advantages, asymmetric epoxidation faces several challenges:
1. Cost of Chiral Ligands: Chiral ligands can be expensive, impacting the overall cost of the process. 2. Substrate Scope: Not all substrates are equally amenable to asymmetric epoxidation. 3. Reaction Conditions: Finding optimal conditions for different substrates can be complex and time-consuming. 4. Catalyst Deactivation: Over time, catalysts can lose their activity, requiring regeneration or replacement.
