Can the ER be Targeted for Therapeutic Interventions?
Given its central role in protein folding and lipid metabolism, the ER is a promising target for therapeutic interventions. Modulating ER function can help treat diseases characterized by protein misfolding, such as cystic fibrosis and certain neurodegenerative disorders. Additionally, targeting ER stress pathways offers potential for cancer therapy, as tumor cells often exhibit high levels of protein synthesis and folding demands.
