RNase H is involved in several critical biological processes. One of its primary roles is in DNA replication, where it removes RNA primers that are laid down during the initiation of DNA synthesis. Additionally, RNase H is vital in the life cycle of retroviruses, as it degrades the RNA template after it has been reverse transcribed into DNA. This step is essential for the integration of viral DNA into the host genome. Moreover, RNase H helps in maintaining genome stability by removing RNA-DNA hybrids that can form during transcription and lead to genomic instability if not properly resolved.
