Despite their advantages, there are some challenges associated with the use of NHCs:
- Air Sensitivity: Some NHCs and their metal complexes can be sensitive to air and moisture, requiring special handling techniques. - Cost: The synthesis of NHCs and their metal complexes can be costly, which may limit their widespread industrial application. - Compatibility: Not all NHCs are compatible with every metal or reaction type, requiring careful selection and optimization for specific catalytic processes.
