Methylenetetrahydrofolate reductase (MTHFR) is an enzyme crucial for the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cofactor involved in the methylation of homocysteine to methionine. Polymorphisms in the MTHFR gene can alter the function of this enzyme, impacting various metabolic processes. Common polymorphisms include C677T and A1298C, which can lead to reduced enzyme activity.
