Achieving high selectivity involves careful consideration of several factors:
Choice of Catalyst: Different catalysts have varying affinities for substrates and can exhibit different selectivities. For example, transition metal catalysts are often chosen for their ability to form specific coordination complexes. Reaction Conditions: Temperature, pressure, and solvent can significantly affect selectivity. For instance, lower temperatures might favor kinetic control, leading to different products than those favored under thermodynamic control. Substrate Structure: The presence of certain functional groups or steric hindrance can influence the pathway a reaction takes, thereby affecting selectivity.
