Substrate inhibition can be modeled using various kinetic equations. The most commonly used model is the Haldane equation, which extends the Michaelis-Menten kinetics to account for inhibitory effects at high substrate concentrations. The equation is given by: v = (Vmax [S]) / (Km + [S] + ([S]^2/Ki)) where v is the reaction rate, Vmax is the maximum rate, [S] is the substrate concentration, Km is the Michaelis constant, and Ki is the inhibition constant.