RNA Polymerase activity is tightly regulated to ensure proper gene expression. Regulation occurs at multiple levels:
Promoter strength: Different promoters have varying affinities for RNA Polymerase, affecting the initiation rate. Transcription factors: These proteins can enhance or inhibit the binding of RNA Polymerase to the promoter. Post-translational modifications: Phosphorylation and other modifications can alter the activity of RNA Polymerase and associated factors. Feedback mechanisms: The products of transcription can influence the activity of RNA Polymerase, creating a feedback loop.
