Folic acid undergoes a series of biochemical transformations in the body, a process that can be likened to a series of catalytic reactions. Initially, folic acid is reduced to dihydrofolate (DHF) and then further to tetrahydrofolate (THF) by the action of enzymes like dihydrofolate reductase (DHFR). THF serves as a cofactor for various enzymatic reactions, including the transfer of one-carbon units in the synthesis of nucleotides and amino acids.
