DNA polymerase activity is tightly regulated through various mechanisms:
1. Protein-Protein Interactions: Interactions with other proteins such as sliding clamps and clamp loaders enhance processivity. 2. Post-Translational Modifications: Phosphorylation and other modifications can modulate the enzyme's activity. 3. Cell Cycle Control: The availability and activity of DNA polymerase are coordinated with the cell cycle to ensure timely DNA replication.
