How Does Metal Catalysis Relate to Neurodegenerative Disorders?
Metals like copper, iron, and zinc are involved in various catalytic processes in the brain. However, dysregulation of metal homeostasis can lead to oxidative stress and the formation of reactive oxygen species (ROS). Excessive ROS can damage cellular components, leading to neurodegeneration. For instance, the role of iron in catalyzing the Fenton reaction, which produces ROS, has been implicated in Parkinson's disease.
