In the context of biocatalysis, MDM2 can be considered an enzyme that catalyzes the ubiquitination of p53. This process involves the transfer of ubiquitin from an E2 conjugating enzyme to the lysine residues on p53. The catalytic activity of MDM2 is crucial for maintaining cellular homeostasis, as overactive p53 can lead to excessive cell death, while insufficient p53 activity can result in uncontrolled cell proliferation.
