Catalysis plays a pivotal role in sialylation by enhancing the efficiency and specificity of the enzymatic processes involved. Glycosyltransferases, particularly sialyltransferases, catalyze the transfer of sialic acid from a donor molecule (usually CMP-Neu5Ac) to an acceptor substrate. The catalytic action of these enzymes ensures that sialylation occurs with high precision and under mild reaction conditions.